Our Task
The world is facing a widespread pandemy of diabetes. We aim to stop and reverse this trend by transforming the clinical protocols that are used to treat the disease.
The world is facing a widespread pandemy of diabetes. We aim to stop and reverse this trend by transforming the clinical protocols that are used to treat the disease.
The Challenge
XX century scientific models of diabetes care were based on several assumptions that are no longer valid -ie. the fate of beta-cells, the feasibility of recovering first phase insulin secretion-. We aim to catalyze and promote the transformation of medical models so we can develop safer, more efficient and cost-effective treatments for prevention and reversion of diabetes.
XX century scientific models of diabetes care were based on several assumptions that are no longer valid -ie. the fate of beta-cells, the feasibility of recovering first phase insulin secretion-. We aim to catalyze and promote the transformation of medical models so we can develop safer, more efficient and cost-effective treatments for prevention and reversion of diabetes.
Our Answer
The IDDR is being developed to identify the factors, levels and interactions that increase the probability of remission in a person with diabetes. The goal is to enable the deployment of novel solutions as fast as possible.
The IDDR is being developed to identify the factors, levels and interactions that increase the probability of remission in a person with diabetes. The goal is to enable the deployment of novel solutions as fast as possible.
Definition of Diabetes Remission
Following international standards [1-3] a person goes into diabetes remission when the following conditions are fulfilled:
We define three levels of remission:
References:
1. Buse JB, Caprio S, Cefalu WT, Ceriello A, Del Prato S, Inzucchi SE, et al. How do we define cure of diabetes? Diabetes Care. 2009 Nov;32(11):2133–5.
2. Riddle, M et al. Consensus Report: definition and interpretation of remission in type 2 diabetes. Diabetologia. 2021 Aug; 64:2359-66.
3. World Health Organization (WHO). Global Report on Diabetes 2016 [Internet]. Geneva: World Health Organization; 2016. Available from: http://www.who.int/diabetes/global-report/en/
Following international standards [1-3] a person goes into diabetes remission when the following conditions are fulfilled:
- Had a diagnosis of diabetes
- Fasting Serum Glucose (FSG) is less than 100 mg/ml (5.6mmol/l)
- HbA1c is less than 6.0% (42mmol/dL)
- There is no active hypoglycemic therapy (either pharmacological or surgical)
We define three levels of remission:
- Initial. When the conditions are fulfilled for three months
- Complete. When the conditions are fulfilled for one year
- Operational cure. When the conditions are fulfilled for five years or more
References:
1. Buse JB, Caprio S, Cefalu WT, Ceriello A, Del Prato S, Inzucchi SE, et al. How do we define cure of diabetes? Diabetes Care. 2009 Nov;32(11):2133–5.
2. Riddle, M et al. Consensus Report: definition and interpretation of remission in type 2 diabetes. Diabetologia. 2021 Aug; 64:2359-66.
3. World Health Organization (WHO). Global Report on Diabetes 2016 [Internet]. Geneva: World Health Organization; 2016. Available from: http://www.who.int/diabetes/global-report/en/